The power blocker just severs the 5V connection from the printer board to the USB port. The printer power supply must be ON when using it with USB since power is not being delivered to the printer board from the USB port anymore. All of our power blockers are tested on a printer before they are sent out.
If you are having issues with the Power Blocker you can try these troubleshooting steps to isolate if you have an issue with the board and/or your USB cable. Your printer power supply must be ON and the printer plugged in to AC power.
When you have the printer connected to Octoprint, you should be specifying the COM port and not relying on the “AUTO” setting. The “AUTO” setting does not work reliably all the time. You should also do a full reboot on the Pi system if you are having issues connecting to your printer.